mdma wiki

In more concrete terms, the drug has a unique touchy-feely pharmacological profile that increases feelings of emotional empathy, closeness with others, and prosocial behavior. The current studies aren’t in agreement as to whether MDMA can cause addiction. MDMA is often called molly or ecstasy and is frequently taken in pill or capsule form. Some people who use MDMA do report symptoms of addiction, including continued use despite negative consequences, tolerance, withdrawal, and craving, according to the NIH. Research in animals indicates that MDMA is neurotoxic and may affect the brain.

Cognitive effects

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Upon a single administration, it takes about 1 month for the tolerance to be reduced to half and 2.5 months to be back at baseline (in the absence of further consumption). It is strongly recommended that one use harm reduction practices when using this substance. Diuretics such as alcohol may exacerbate these risks further due to causing excessive amounts of dehydration.

mdma wiki

Thanks to oxytocin, many people describe feeling “loved up” while under the influence of MDMA. MDMA is a psychedelic compound that is structurally similar to amphetamine, a stimulant that accelerates activity in certain regions of the brain, and mescaline, a hallucinogen. MDMA exerts a unique set of effects on the brain that enable it to treat diverse mental illnesses, such as anxiety, depression, and PTSD. While it shares characteristics with other psychedelic compounds, it differs in some ways too. MDMA is a psychedelic often referred to as the “hug drug.” With a reputation as a party pill, MDMA can heighten sensations and enhance social connection. However, this potent compound boasts therapeutic uses that extend far beyond its ability to bring good feels at a rave.

It may be able to help those dealing with trauma to feel safe and capable of breaking out of harmful thought patterns. When you contact 911, always let them know what drugs the person took and how much. Fentanyl can make drugs it’s mixed with, including MDMA, more dangerous. Often, people who purchase MDMA and other drugs are unaware those drugs have been cut with fentanyl.

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Molecules of the amphetamine class all contain a phenethylamine core comprised of a phenyl ring bound to an amino (NH2) group through an ethyl chain, with an additional methyl substitution at Rα. In addition to this, MDMA contains a methyl substitution on RN, a feature it shares with methamphetamine. Critically, the MDMA molecule also contains substitutions at R3 and R4 of the phenyl ring with oxygen groups — these oxygen groups are incorporated into a methylenedioxy ring through a methylene bridge.

See this article and this article about clinical research into medical uses for MDMA. Dr Bronner’s has generously donated, though millions more in funding is needed. Evidence suggests MDMA is well-suited to treat a wide range of other disorders too, such as depression, anxiety disorders, obsessive-compulsive disorder, suicidality, substance use disorders, and eating disorders. MDMA was first synthesized by Merck, a German pharmaceutical company, back in 1912 as a medicine to control bleeding. The compound slipped into disuse and fell off the radar until the late ‘70s, when a group of underground psychotherapists investigating psychedelic therapy stumbled across it. MDMA became increasingly popular in their underground therapy sessions; these trailblazing psychotherapists found it helped patients to open up and achieve insights into their problems.

Psychedelic and Dissociative Drugs

MDMA also carried a significantly lower risk of anxiety and “bad drug effect,” or flipping out while tripping. MDMA is a drug that’s commonly thought of as a party drug and is known for producing feelings of pleasure, energy, and positive emotion, along with altered sensory perception. Other drugs in this chemical group include methamphetamine and cathinone. Current regulations have classed MDMA as a Schedule 1 controlled substance. This means that it’s thought to have a high potential to be abused and that it’s not legally considered to have health benefits.

Effects

For example, a metabolite of MDMA called alpha-Methyldopamine (α-Me-DA, which is known to be toxic to dopamine neurons7518) was thought believed to be involved in the toxicity of MDMA to serotonin receptors. Recent evidence suggests the safe and potentially effective use of MDMA to treat the negative symptoms of schizophrenia.310 Unlike other treatments for mental illness, MDMA would be intended to be used infrequently and alongside psychotherapy in treatment. In Australia, MDMA was rescheduled on 1 July 2023 as a schedule 8 substance (available on prescription) when used in the treatment of PTSD, while remaining a schedule 9 substance (prohibited) for all other uses. Permits for research uses on humans must be approved by a recognized ethics committee on human research. The Food and Drug Administration (FDA) has designated MDMA-assisted psychotherapy for people with PTSD as a breakthrough therapy.

Read more of Leafly’s guide to psychedelics

There is a horribly toxic chemical with a four-letter acronym, MPTP, which does cause parkinsonism. It has appeared as an unwanted impurity in a heroin-like (opiate) drug called MPPP, causing the people who took the contaminated drug to ‘freeze up’ by destroying dopamine neurons in the brain, just as Parkinson’s disease does. Like most illegal drugs, the purity of MDMA changes all the time, so forms that might once have been more reliable cannot be guaranteed to remain so. It is quite easy for drug dealers to mix MDMA powder with any substance that looks like it, so taking MDMA powder does not necessarily mean you are not unknowingly taking other substances mixed with the drug.

Medical

Users are advised to pay close attention to their water intake, drinking neither too much nor too little, and to take care not to overexert themselves to avoid heat-stroke, which can be fatal. Crystals or powder (commonly called Molly) is a white to brownish substance which can be dissolved, crushed, put into gel capsules or edible paper (“parachutes”). It can be administered orally, sublingually, buccally mdma wiki or via insufflation (“snorting” or “sniffing”). It is highly advised to use harm reduction practices if using this substance.

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